A member asked:

Positive ana titer 1:80 homogenous in my 10 year old daughter. chronic fatigue and repeat kidney infections. could it be pediatric systemic lupus?

5 doctors weighed in across 4 answers
Dr. Gloria Lopez answered

Specializes in Pediatrics

It could: ANA (antinuclear antibodies) are a group of auto-antibodies produced by a person's immune system when it fails to adequately distinguish between "self" and "nonself" and cause organ and tissue damage. It’s most often used as one of the tests to help diagnose systemic lupus erythematosus (SLE). 97 % of patients with lupus will have a positive antinuclear antibody test (ANA).

Answered 11/28/2017

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ANA: The ANA, antinuclear antibody, is a nonspecific test that might suggest a connective tissue disorder, but might not. I'm wondering why the test was sent. In any case, given the result, it would be reasonable for your provider to either send off a more complete panel of tests, or refer your daughter to a Rheumatologist.

Answered 11/28/2017

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LUPUS: Lupus test has to become positive for DX.ANA is also positive in other collagen diseases .

Answered 7/10/2014

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Dr. Christine Hom answered

Specializes in Pediatrics

Unlikely: Kidney infections are not typical for lupus. Patients with lupus can have fatigue, but they also have very specific findings like anemia, arthritis, rash, mouth sores, protein in the urine.

Answered 8/27/2015

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