A member asked:

Can very high positive ana alone possibly make one feel tired and just not well when other labs are currently normal in person with lupus/sjogren.how?

A doctor has provided 1 answer
Dr. Thomas Namey answered

Specializes in Rheumatology

No.: A high titer ANA is not a good correlate of disease activity. Talk to your provider. Only actual clinical problems or specific antibody titers correlate with disease activity. I have many patients with high titer anas and no systemic lupus erythematosis or sjogren's disease activity whatsoever.

Answered 9/30/2019

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