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A member asked:
I have been diagnosed by my allergist with idiopathic angioedema. a couple of years ago when blood work was originally done i also had an elevated ch50 count. all other looked good. my doctor is not concerned about systemic issues. should i be?
A doctor has provided 1 answer
An elevated CH50 has no specific clinical significance other than to reflect that complement proteins increase as part of the acute-phase response. In angioedema, low CH50 may indicate hereditary angioedema and that's why it was ordered along with other complements. No further study needs to be done if CH50 is high but other complements are normal and you have no other symptoms besides angioedema.
Answered 6/16/2023
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