A member asked:

Could treatment for gon/chlam w/ ceftriaxone and azith cause an rpr test to be false neg 3 months later? initial exposure was oct 18, and gon/chlam treatment was oct 30. rpr was done mid feb and neg. hiv neg. no other exposures. conclusive result?

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Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

One dose of ceftriaxone is not effective for treating primary or secondary syphilis but a 2 gm dose azithromycin may be effective if you did not acquire macrolide-resistant T. pallidum which is present in multiple U.S. geographic areas. So if you received 2 gm of azithromycin and the T. pallidum is not resistant to this antibiotic, you may be cured with that dose and the RPR may become negative.

Answered 4/30/2022

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