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A 67-year-old male asked:

Ive had an enlarged prostate for 4-5 yrs. this time the doc said i need a biopsy. bc the psa test came back at 10.9 . i refused it and had another psa text, it came back at 1.0 is this possible ?

2 doctor answers3 doctors weighed in
Dr. Bennett Machanic
Neurology 52 years experience
Unfortunately, hard to say which test was accurate. Need to get a second opinion regarding status of the prostate, and question of a biopsy.
Dr. Hiep Le
Dr. Hiep Leanswered
Nephrology and Dialysis 42 years experience
It is possible. PSA level result is not always reliable and you were right when asking for a retest. The incremental change in PSA level is more reliable. If the level was 2.5 in 2018, 4.0 in 2019 and then 6-9 in 2020 (still less than 10), prostate biopsy is likely indicated. In your case, you need to have another level check in 3 months with same laboratory facility.

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Last updated Mar 11, 2021

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