A member asked:

Concerning prozone do antibody levels change could you have a high level causing a false neg. rpr then they drop 2nd test n get + test?

A doctor has provided 1 answer

Possible: Antibody levels do change. They start out low, increase and could reach levels to cause prozone phenomenon and then drop with time. If prozone is a concern, your laboratory can make dilutions of the sample to address this issue. You may wish to talk to the pathologist in-charge of the lab that did the tests.

Answered 5/20/2019

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