A member asked:

Confusing for me, syphilis, not here to frustrate drs last talk as i mentioned test neg at 8 weeks rpr while on z pak a day before and then waited i make sure didnt take any antibiotics then test again at 16 wek neg rpr no need for additional test?

2 doctors weighed in across 2 answers

Syphilis can have a long lag period for the tests to turn positive. Get tested again at 6 months after exposure. Syphilis window period: https://www.e7health.com/post/155/std-test-window-when-should-i-get-tested/#:~:text=The%20average%20window%20period%20or,it%20develops%20in%20three%20stages. https://www.cdc.gov/std/syphilis/stdfact-syphilis-detailed.htm

Answered 9/24/2022

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Dr. Hunter Handsfield answered

Specializes in Infectious Disease

Even if truly exposed to syphilis, azithromycin (Z pak) might have aborted it, preventing a test to be positive, However, almost half of all syphilis is resistant to azithromycin. Either way, your negative RPR at 16 weeks is conclusive proof you do not have syphilis.

Answered 8/30/2023

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