A member asked:

Gad. on dothiepin 31.25mg, lexotan 0.375mg 1 year. dry eyes. doc said stop doethiepin, take lexotan 1.5mg. can stop without taper? scared of rebound.

A doctor has provided 1 answer

Tricyclic withdrawal: Dothiepin 31.25mg/day is a small dose; risks for side effects of withdrawal are much less than at high doses. Tricyclic antidepressant withdrawal can be unpleasant, w mood symptoms including irritability & insomnia, & flu-like physical symptoms. There can even be dangerous heart rhythms (rare); no-one should stop these medicines abruptly on his/her own without discussing w prescriber.

Answered 10/24/2017



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