A member asked:

Can wellbutrin (bupropion) affect serotonin levels?

A doctor has provided 1 answer

No: Preclinical and clinical data demonstrate that bupropion acts via dual inhibition of norepinephrine and Dopamine reuptake, which constitutes a novel mechanism of antidepressant action. As such, bupropion is associated with a unique clinical profile with efficacy comparable to that of other antidepressants. Devoid of clinically significant serotonergic effects... www.ncbi.nlm.nih.gov/pmc/articles/pm.

Answered 6/2/2017

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