Can taking wellbutrin (bupropion) and zoloft and smoking cannabis cause serotonin syndrome? i've had a few panic attacks that i am worried may actually be ss

Cannabis & serotonin: Cannabis can increase serotonin levels, and definitely should not be used with ssri's like zoloft (sertraline). In fact if you've been struggling with depression and/or anxiety, using any additional drugs is a really bad idea.

Cannabis?: Cannabis can cause anxiety, panic attacks and even paranoia. With the problems you have and the medications you take, maybe it would be best to not use cannabis? I would discuss this with your physician to come up with a plan to best address your concerns.