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A member asked:
Does cymbalta (duloxetine) have to build up in your system if your talking it for joint pain or does it work right away?
11 doctors weighed in across 3 answers
Not a pain reliever: Cymbalta (duloxetine) is a unique medication for chronic pain. It increases the serotonin and norepinephrine between nerve cells. It does take some time (days-weeks) for this to happen. It doesn't work like other short-acting pain relievers such as ibuprofen.
Answered 6/24/2014
4.7k views
Within 1st week: Duloxetine: a review of its pharmacology and use in chronic pain ... www.ncbi.nlm.nih.gov/pubmed/20921842 by ga bellingham - 2010 - cited by 20 - related articles analgesic onset has been observed within the first week of administration in randomized controlled trials ... Compared with other antidepressants or anticonvulsants for the treatment of pain syndromes.
Answered 11/23/2013
4.7k views
Takes about: 14 days to appreciate pain benefits,
Answered 11/27/2017
505 views
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