Taper: The best way to get off of most psychiatric medications is to taper the dose (after talking to your doctor, of course). Cymbalta (duloxetine) has an "elimination half life" of about 12 hours. That means after twelve hours about half of the drug is gone from your body. For practical purposes, 4 or 5 elimination half lives is enough for the medicine to be gone from your system. So about 2 to 2 and a half days.
Answered 6/24/2014
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