A member asked:

What causes pernicious anemia and a mild increase in gamma globulin?

A doctor has provided 1 answer
Dr. Michael Engel answered

Specializes in Pediatric Hematology and Oncology

Pernicious anemia...: Is due to B12 def arising from loss of intrinsic factor production by parietal cells in the stomach and required for B12 absorption in the gut. Anything that produces B12 def can cause these symptoms. Classically, pa is one such diagnosis that is due to destruction of parietal cells by the immune system (ie., an autoimmune disorder). I suspect elevated igg is true, true and unrelated. See your dr.

Answered 2/14/2021

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