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A 30-year-old member asked:

Is methadone a cause of pernicious anemia?

3 doctor answers5 doctors weighed in
Dr. Ed Friedlander
Pathology 46 years experience
No: I wish every question were this easy to answer. Methadone treatment is a great blessing for many people. Classic pernicious anemia is an autoimmune disease involving the stomach interfering with B12 absorption. It is possible for a person taking Methadone to develop it, but it would be a coincidence.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Alan Wartenberg
A Verified Doctoranswered
Addiction Medicine 51 years experience
No: Unaware of any association. True pernicious anemia is an autoimmune disease, caused by antibodies to the cells in our stomachs that produce intrinsic factor, which is needed to absorb vitamin B12 from our intestines. It may be hereditary or acquired. There are other causes of B12 deficiency, including stomach and intestinal diseases/surgery, and lack of B12 in diet. A hematologist can help.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Stephen Kibrick
Clinical Psychology 48 years experience
Not likely: Methadone is a very strong opioid medication, with a long list of serious side effects. But pernicious anemia is NOT one of them. Contact your doctor for specific information about your case, re your anemia and specific doses of methadone you are taking. Anemia may be related to other meds you are taking, or an underlying illness. Check with your MD.
Created for people with ongoing healthcare needs but benefits everyone.

Similar questions

A 32-year-old member asked:

What are the causes of pernicious anemia?

1 doctor answer2 doctors weighed in
Dr. Romeo Mandanas
Hematology and Oncology 40 years experience
Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray).
Created for people with ongoing healthcare needs but benefits everyone.

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Do you know what is the intrinsic factor and how it causes pernicious anemia?
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Last updated Mar 3, 2017

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