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A 44-year-old member asked:

Cymbalta, (duloxetine) when is it best to take?

3 doctor answers11 doctors weighed in
Dr. Jeffrey Desarbo
Psychiatry 21 years experience
What's best for you: Most people take Cymbalta (duloxetine) in the am and tolerate it well. However, some people feel mildly tired and i let them take it in the pm. As long as it doesn't interfere with sleep than that is fine. If you are experiencing GI side effects on a high dose you may need to divide the dose and take it twice a day. Do take it daily around the same time each day.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 33 years experience
Cymbalta (duloxetine): Some sedation is expected at higher dosage. Best to take main dose in evening.
Dr. Shariq Refai
Psychiatry 14 years experience
Usually: Usually taken in the morning as it can affect sleep for most. But take it depending on how you reeact to it. If you take it and it makes you tired then take it at bedtime. If you take it and it keeps you awake then take in the morning. Once you learn when the best time to take it is for you then take it each day at that time.
Last updated Aug 28, 2018
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