I've lupus (sle), r.a., raynaud's syndrome, anemia, &hypertension. i take methotrexate, plaquenil, (hydroxychloroquine) neurontin & lisinopril/hctz. i'm told i've decreased kidney function.is that because of the medication?

Probably not: Lupus usually damages the kidneys and hypertension always does to some extent. Not all "decreased kidney function" picked up by today's lab screenings is real kidney damage -- any guy who lifts weights will get a warning from the creatinine from his muscles -- but i'd keep with your rx. Good luck -- this is a challenging disease.

Maybe: Lupus itself can harm the kidneys, and so can hypertension. Methotrexate, lisinopril, and hctz (hydrochlorothiazide) could also cause renal failure.

See below: If you have not seen a nephrologist, you need to do so. An urinalysis should have been performed to look for active sediment and proteinuria---if these are present, you would have to a kidney biopsy. If your urine did not show active sediment or proteinuria then it may have been the medications that affected your kidney function.