I have postural orthostatic tachycardia syndrome from lupus. i only take plaquenil (hydroxychloroquine) since lupus gave me pots is that a poorer prognosis since its the nervous system (i heard if it affects cns its bad)?

SLE: Each individual with sle is different, and the major debilitating organ damage is usually kidneys. Without knowing whether your pots is actually related to the sle or some other cause, the best advice i could give you is to talk to the doctor caring for you. Good luck.

YES and many more : Few listed: cardiomyopathy (rare, relationship to Hydroxychloroquine unclear) central nervous system: ataxia, dizziness, emotional changes, headache, irritability, lassitude, nervousness, nightmares, psychosis, seizure, vertigo dermatologic: alopecia, angioedema, bleaching of hair, pigmentation changes (skin and mucosal; black-blue color), rash (acute generalized exanthematous pustulosis, etc.