In january 2022 my liver enzymes were normal. they've progressively gone up and today ast was 75, alt was 230. i have lost 125 pounds in the past 2 years. i am vaccinated to hep. no tylenol or alcohol. no meds that metab in liver. any ideas?

What is the reason for that significant weight loss? There are other liver conditions which result in abnormal liver enzymes besides viral hepatitis, alcoholic liver disease or drug-induced hepatitis. I wonder if there is relationship between the weight loss last 2 years and current abnormal liver test. You should be evaluated by a gastroenterologist or a liver specialist.

If your weight loss was unintended, it would suggest a disease process that may be affecting the liver as well. It is not feasible to provide a meaningful opinion without additional history, physical examination and may be some tests. It would be prudent to see a doctor, preferably a gastroenterologist. Wish you good health!