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A member asked:
Have any of you doctors had a patient who complained about getting mental fog and anxiety from angiotensin receptor blockers (particularly valsartan)? do arbs lower the level of norepinephrine in the brain? i read that they increase acetylcholine?
A doctor has provided 1 answer
Each medication has its own side effects which could be rare but it does happen. If my patient experiences a new symptom after taking a new med I always take it seriously. If sx seems tolerable I will advise to continue and most will overcome it after a couple weeks. However, if the sx seems intolerable, I will change to a different med in the same group as a trial. Ask your doc for an alternative
Answered 12/30/2022
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Question for doctors that prescribed angiotensin receptor blockers for hypertension... which ARB did your patients complain least about (had least side effects)? And which one was more problematic than others... Thanks?
Do Angiotensin Receptor Blockers cause insomnia or sleep interruptions? I take Valsartan 40mg and I also have mild sleep apnea but I'm wondering whether the ARB is making my sleep worse because I wake up frequently and I get strange dreams?
Do Angiotensin Receptor Blockers affect cognitive function, concentration or memory? I'm aware that beta blockers can cause depression because they affect norepinephrine but what effect do ARBs have on brain neurochemistry?
What effect would you expect Angiotensin Receptor Blockers to have on the brain RAAS in people with Attention Deficit Disorder? Reduction in norepinephrine and sympathetic down regulation through AT1 blockade would reduce attention span and memory?
Is it possible that when you give someone Valsartan or any other Angiotensin Receptor Blocker their sympathetic nervous system gets more activated and they become more hyper aroused in response to emotional stressors?
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