Get Virtual Care
For Businesses
About Us
A member asked:
My kappa flc count is a 2.17 mg/dl (range on test is .33 - 1.94 mg/dl) and my lambda count is 1.31 mg/dl (range is .57 - 2.63 mg/dl) ratio is 1.66 (range .26 - 1.65) spep is normal? should i be worried about ratio being .01 outside of normal range?
2 doctors weighed in across 2 answers
Although the ratio is only .01 above the upper limit of normal but serum kappa FLC is high so the result has to be interpreted cautiously. I wonder if you have 24 hour urine collection and or urine immunofixation. If kappa light chain is high in the urine, kappa light chain disease may be present. I assume your kidney function is still normal because those light chains are much higher in CKD.
Answered 11/9/2022
0 views
No. A kappa/lambda ratio is of limited usefulness. A normal ratio does not exclude disease and an abnormal ratio is not diagnostic of anything. Your results are not a cause for any concern. Wish you good health!
Answered 11/9/2022
0 views
Related Questions
A member asked:
Gave plasma, leading to tests (cbc, SPEP, immunofixation, FLC). Waiting for hemo consult. Have high IGA (7.09g/l) but low IGG (3.05) &low IGM(.15). Monoclonal IGA type lambda found (8.5mg/l), lambda=33.4mg/l, but LC ratio ok. Am I immune compromised?
2 doctors weighed in across 2 answers
A member asked:
Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.
2 doctors weighed in across 2 answers
A member asked:
Question about lab results from hematologist. Free kappa light chains serum 19.97 (range is 3.30-19.40mg/l) Normal lambda and ratio.
A doctor has provided 1 answer
People also searched for:
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
This is for my mother, aged 55. High serum kappas (33), normal lambdas and marginally high kappa lambda ratio (1.9). SPEP and Immunofixation show polyclonal gammopathy (in IgG Kappa and Lambda). Should we be concerned about MGUS/Myeloma ?
I have a kappa/lambda ratio of 2.49, kappa lt chain is 18.7, lambda lt chain is 7.5. SPEP looks normal. ESR is 21. CRP is 3. I am JAK2 positive. Should I be concerned?
Polyclonal IGA rise on SPEP,no Mprotein on IFE (IGA,IGG,IGM and FLC) . FLC results (turbidimetry) kappa-5.80 mg/l ref. 1.41-8.29 lambda-3.70 H mg/l ref. 0.64-2.97 ratio-1.57 ref. 0.99-6.25 difference between turbidimetry and nephelom?
Dr ran a protein electrophoresis test on me (both urine and blood). Kappa light chains slightly elevated/flagged in serum (21.5) but normal range in urine. No M spike observed and all other values normal. Chances of cancer small?
Didn't find what you're looking for?
90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.
Ask your questionMore of what we treat
Download HealthTap
Video visit and message your doctor
