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A member asked:
This is for my mother, aged 55. high serum kappas (33), normal lambdas and marginally high kappa lambda ratio (1.9). spep and immunofixation show polyclonal gammopathy (in igg kappa and lambda). should we be concerned about mgus/myeloma ?
A doctor has provided 1 answer
No need for concern. More than 30% of people your mother's age have a marginally abnormal kappa lambda ratio with excess kappa. More than 50% of the people with polyclonal gammopathy have a kappa dominant kappa lambda ratio without having MGUS or myeloma. For info: J Appl Lab Med . 2020 Nov 1;5(6):1358-1371. doi: 10.1093/jalm/jfaa153.
Answered 2/7/2022
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