A 31-year-old male asked:
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serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. likely mgus, myeloma, or admyloidosis? cbc/met panel ok.

2 doctor answers
Dr. Gurmukh Singh
48 years experience Pathology
False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex.
Answered on Aug 26, 2019
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Dr. Ed Friedlander
43 years experience Pathology
None of the above: With no monoclonal protein in serum or urine, all of these are unlikely. I would not be concerned in the least about being a guy who just happens to make more kappa than lambda antibodies. You know that reference ranges are set so that maybe 5% of healthies fall outside. You're 31. Get / stay fit, find / share love, work hard career-building, and enjoy being young. Best wishes.
Answered on Aug 26, 2019
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