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Reno, NV
A 50-year-old female asked:

My total protein had been increasing, so my dr had me test for multiple myeloma. protein had come down to normal,no m-spike observed, everything normal except a slightly elevated kappa of 21.5 in serum (but normal in urine). could i still have cancer?

2 doctor answers3 doctors weighed in
Dr. Donald Colantino
Internal Medicine 61 years experience
Cancer: Rarely multiple myeloma can be present with normal serum electrophoresis but immunofixation may show it. Your free light chain assay showed what you say is a slightly elevated kappa level of 21.5/L, but I note that up to 26.3 is normal. The bottom line is, if you have no suspicious symptoms, I would be reassured. If there are symptoms, bone marrow biopsy would be done. Your MD is best to advise yo
Dr. Gurmukh Singh
Pathology 49 years experience
Agree with Dr. C: Serum free light chain assay adds little to diagnostic work up. One third of people, without multiple myeloma, who come to a tertiary care center have an abnormal kappa/lambda ratio. Have a healthy diet, exercise 30 minutes/day, drink plenty of water, have safe sex, no tobacco alcohol weed or street drugs. For nutrition: http://www.choosemyplate.gov/. Get HPV vaccine. Wish you good health!

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Last updated Aug 27, 2020
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