Side effect of PPI : The chronic use of PPI such as omeprazole is fairly common in medical practice especially GERD or in patients at increased risk of PUD , but has been associated with causing vitamin B12 deficiency.Omeprazole's ability to suppress gastric acid production can impair the conversion of pepsinogen to pepsin, which can affect the ability of protein bound vitamin B12 to be freed for absorption.
Answered 7/8/2019
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