Reasonable choice: It usually isn't possible to know the exact bacteria involved in any particular case of bacterial sinusitis, and that's what determines which antibiotic(s) will work best. Therefore, it's pretty much a guessing game. Doxycycline is a reasonable choice after levofloxacin didn't work. However, it's possible no antibiotic will help; adequate drainage may be equally or more important.
Answered 4/21/2018
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