THERE ARE: Three categories: erythromelalgia (platelet-mediated and aspirin-sensitive), primary erythermalgia, and secondary erythermalgia Hereditary erythromelalgia is an autosomal dominant disorder caused by mutations in a protein involved in a , voltage-gated sodium channel. More than 20 SCN9A mutations have been reported in patients with this form of primary erythromelalgia. Causes of secondary erythromelalgia include medications, myeloproliferative disorders, infections and unknown causes. The early-onset (primary) form is reported to have a male-to-female ratio of 1:2.5. Secondary erythromelalgia was reported to have a male-to-female ratio of 3:2 when due to myeloproliferative disorders but a 1997 case series from Norway showed a female predominance (male-to-female ratio of 1:2), when a variety of causes were included.
Answered 4/8/2017
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