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A member asked:
Serum free light chain ratio is normal but lambda ife in 24 hour urine. renal and anemia but normal ca. is there reason for more mm workup bm biopsy?
A doctor has provided 1 answer
Yes: Light chain ratio is unreliable. If you have monoclonal lambda chain in urine, you need to have bone marrow examination for myeloma work-up.
Answered 11/28/2017
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Related Questions
A member asked:
Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow
5 doctors weighed in across 2 answers
A member asked:
Pathology - Just got my blood results back says kappa / Lambda light chains free with ratio urine came 18 high / prostaglandin serum 550 ? What's mean
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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
2 doctors weighed in across 2 answers
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