A member asked:

The question is not about me i understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder but what is a blastic transformation of the disorder? is it the same thing as an ac?

5 doctors weighed in across 2 answers
Dr. Charles Gordon answered

Specializes in Adolescent Medicine

Transformation : Cells keep on growing in stages from one to another to another. When they are in the blastic stage they have regressed to a very rapidly growing stage. That's what happens in cancers. We try to kill those very rapidly growing cells and push them back into more "well behaved" cells.

Answered 1/3/2016

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Dr. Matthew Fero answered

Specializes in Medical Oncology

Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing.

Answered 1/14/2016

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