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A member asked:
The question is not about me i understand that an acute transformation of overlap myeloproliferative/myelodyplastictiy disorder is the terminal phase of the disorder but what is a blastic transformation of the disorder? is it the same thing as an ac?
5 doctors weighed in across 2 answers
Transformation : Cells keep on growing in stages from one to another to another. When they are in the blastic stage they have regressed to a very rapidly growing stage. That's what happens in cancers. We try to kill those very rapidly growing cells and push them back into more "well behaved" cells.
Answered 1/3/2016
1.8k views
Acute vs blastic?: In the chronic and dysplastic hematologic malignancies that you mention (CMML and MDS), the term "acute" transformation means an evolution to acute leukemia. This is defined as more than 20% "blast" cells microscopically. Therefore acute and blastic transformation are the same thing.
Answered 1/14/2016
1.8k views
Related Questions
A member asked:
Infection makes it harder to recover from an acute transformation of a myeloproliferative disorder But can the antibiotics also have an adverse effect?
6 doctors weighed in across 2 answers
A member asked:
85 year-old friend has for 2 weeks had his temp < 36C 19 times out of 34 readings. I don't understand this inconsistency. WBC is moderately hi & CRP very hi & going up. Could the temps be due to his overlap myeloproliferative-myelodysplastic disorder?
3 doctors weighed in across 2 answers
A member asked:
Are any of (1) overlap myeloproliferative/myelodysplastictiy disorder (2) monoclonal B cell lymphocytosis or(3) monoclonal gammopathy ever familial?
A doctor has provided 1 answer
A member asked:
Could you please tell me whether JAK-2 overlap myeloproliferative/myelodysplastic disorder is familial?
A doctor has provided 1 answer
People also searched for:
Are there any treatments for acute transformation of overlap myelodysplascity/myeloproliferative disorder in an elderly patient If so, what are they?
A relative has an overlap myeloproliferative/myelodysplastic disorder. He has been told that if it changes into an acute transformation then it may be life-threatening. However, is there some other possible change that could ALSO be life-threatening?
In general, if a 91 yr-old has acute transformation of a myeloproliferative disorder then is it worthwhile to treat the pt, if there is a treatment?
I would appreciate some clarity on an important matter. Are myelodsyplastic and myeloproliferative disorders pre-malignant conditions or are they malignancies by their very nature even before an acute transformation has occurred?
Are all acute transformations rare or is there good evidence that the probability of such an occurrence depends upon the particular type of underlying myeloproliferative disorder that a person has? I'm told that there is more than one type of MD.
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