What effect can weed have on wellbutrin (bupropion) and zoloft?

Probably not good.: A fully informed answer can't be given, if only because "weed" is not standardized in the way that Wellbutrin (bupropion) and Zoloft are. But the concerns are: direct or indirect interference with the pharmacodynamics and phramcokinetics of the medicines; continuation of the underlying problems by virtue of avoidance or addiction. On the other hand, some people use it and still benefit from the meds