A member asked:

Is wellbutrin (bupropion) xl 150mg and zoloft 50mg a safe combination to take? i've read a lot of mixed answers.

A doctor has provided 1 answer

SHOULD BE OK: This is not an unusual combination and is worth trying a Zoloft is a selective serotonin reuptake inhibitor and Wellbutrin (bupropion) is a dopamine and norepinephrine reuptake blocker. So these two medications augment each other. The doses that you are trying are certainly conservative enough.

Answered 10/3/2014

3.7k views

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