Can i take zanaflex (tizanidine) and zyrtec d together? treating a sinus headache.

There is a precautio: Caution is advised due to the combination of these two medications can increase the risk of ccentral neurological sytem depression and can lead to psychomotor impairment

Not appropriate use: Zanaflex (tizanidine) is a muscle relaxer (http://www.drugs.com/zanaflex.html) so it's not intended for use in treating sinus headaches. Moreover, use of Zanaflex (tizanidine) w/ZyrtecD (antihistamine w/decongestant) runs risk of drowsiness, dizziness, lightheadedness, difficulty concentrating, and impairment in thinking and judgment. You didn't ask but definitely don't recommend concomitant alcohol. http://goo.gl/w30maz