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Wichita, KS
A 28-year-old female asked:

Can i take zanaflex (tizanidine) and trazodone together?

3 doctor answers3 doctors weighed in
Dr. Mohammed Younus
33 years experience
You may: There is additive effect of sedation other wise there is low level drug drug interaction between Zanaflex (tizanidine) and trazodone, but overall safe.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. L. Stoney
Pain Management 40 years experience
Sleep: The combination of Zanaflex (tizanidine) and trazadone may lead to a difficulty during the night and next day. Both are sedating medications but the combination may lead to excessive sedation the following day.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 34 years experience
Zanaflex (tizanidine): Combined with trazodone and klonopin, (clonazepam) excess sedation is likely, depending on the dose of each.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated May 29, 2021
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