You may: There is additive effect of sedation other wise there is low level drug drug interaction between Zanaflex (tizanidine) and trazodone, but overall safe.
Answered 5/29/2021
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Sleep: The combination of Zanaflex (tizanidine) and trazadone may lead to a difficulty during the night and next day. Both are sedating medications but the combination may lead to excessive sedation the following day.
Answered 9/26/2020
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Zanaflex (tizanidine): Combined with trazodone and klonopin, (clonazepam) excess sedation is likely, depending on the dose of each.
Answered 12/17/2019
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