A member asked:

Can i take zanaflex (tizanidine) and trazodone together?

3 doctors weighed in across 3 answers

You may: There is additive effect of sedation other wise there is low level drug drug interaction between Zanaflex (tizanidine) and trazodone, but overall safe.

Answered 5/29/2021

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Dr. L. Stoney answered

Specializes in Pain Management

Sleep: The combination of Zanaflex (tizanidine) and trazadone may lead to a difficulty during the night and next day. Both are sedating medications but the combination may lead to excessive sedation the following day.

Answered 9/26/2020

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Dr. Alan Ali answered

Specializes in Psychiatry

Zanaflex (tizanidine): Combined with trazodone and klonopin, (clonazepam) excess sedation is likely, depending on the dose of each.

Answered 12/17/2019

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