SPEP FLC Lab tests: The serum protein electrophoresis (SPEP) with immunofixation (IFE) and the free light chain (FLC) kappa to lambda ratio tests are related and complementary laboratory tests for plasma cell dyscrasias such as multiple myeloma. Screening is often done with both SPEP + FLC and both can be used to follow myeloma treatment. If SPEP is negative, FLC k/l ratio can still be abnormal.
Answered 7/17/2015
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