A member asked:

Spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. my pcp wasn't worried, didn't want to test further. should i be concerned?

3 doctors weighed in across 2 answers

M-protein: At your age, monoclonal gammopathy of undetermined significance (mgus) or frank myeloma, is extremely unlikely. These disorders are more common in people of african-american descent in older sge groups. Usually, these bands at your age are benign and warrant only periodic follow up.

Answered 10/3/2020

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Dr. Thomas Namey answered

Specializes in Rheumatology

At your age, no!: A monoclonal gammopathy is rare at your age. Number two, they takes decades usually to express themselves. Number three, not all become multiple myeloma, and number four, multiple myeloma is no quite treatable. I have many patients followed for years in late seventies, who still rquire no treatment. Simply repeat the test yearly. I would quantify the specific gammaglobulins as well, yearly.

Answered 10/3/2020

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