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Port Huron, Michigan
A 28-year-old female asked:

How long before i know this cymbalta (duloxetine) is working thoroughly?

2 doctor answers2 doctors weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Cymbalta (duloxetine): For depression, can take up to 4-6 weeks for full response at optimum dose.
Dr. Robert Olsen
Psychiatry 51 years experience
Up to 6 weeks & more: A problem with antidepressants: there is no sure-fire way to pick one that will work for sure; and no sure fire way to get the correct dosage right off the bat. If you have taken Cymbalta (duloxetine) at a stable dosage for 6 weeks with no change in symptoms, you need either a changed dosage or another or a different medication; increasing dosage is usual next step before switching or adding medications.

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Last updated Jun 24, 2014

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