I have tried many types of medication for depression but none of them have worked. what should i do?

Many possibilities: It can be challenging to find a medication that works and continues to work, but it can be done. First, talk with your doctor -- & if it's not a psychiatrist, get referred. Psychiatrist will go over your entire history, & with specialized training may be able to offer something new & helpful to you. Psychotherapy is very important too. Other treatments like tms & ECT are additional options.