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A 26-year-old member asked:

Does taking tamoxifen for breast cancer treatment cause cancer of the uterus ?

2 doctor answers7 doctors weighed in
Dr. Barry Rosen
General Surgery 34 years experience
Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this is almost-always caught at its earliest stage, with very high cure rates. If you compare the benefit of tamoxifen for either treating or preventing breast cancer compared to this risk, the benefit far outweighs the risk.
Dr. Valentin Drezaliu
Obstetrics and Gynecology 20 years experience
Tamoxifen: If you get vaginal bleeding, you need a biopsy of the endometrium. Some doctors do ultrasounds looking for polips as well

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A 35-year-old member asked:

Can taking tamoxifen for breast cancer treatment induce cancer of the uterus ?

1 doctor answer3 doctors weighed in
Dr. Mark Hoepfner
General Surgery 39 years experience
Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much higher than the risk of endometrial cancer. Ask your oncologist and ob-gyn how best to follow or watch for this potential risk.
A 50-year-old member asked:

Does taking tamoxifen for breast cancer treatment induce development of cancer of the uterus?

2 doctor answers8 doctors weighed in
Dr. Barry Rosen
General Surgery 34 years experience
It can.: Studies show that women who take tamoxifen have twice the risk of uterine cancer as compared to non treated patients. However, the benefits of tamoxifen for the treatment of breast cancer far outweigh the risks. Aromatase inhibitors are a group of drugs that can be used instead of tamoxifen for post-menopausal breast cancer patients; these drugs do not have this risk.

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Last updated Dec 4, 2014

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