A 41-year-old female asked:
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what could replace tamoxiphen in second 5 years after breast cancer? tamoxiphen caused me ovarian cyst and uterus thickening . thanks

2 doctor answers
Dr. Addagada Rao
55 years experience General Surgery
May be Femara (letrozole): Letrozole ( Femara (letrozole) ) also redices estrogen levels , discuss with your oncologist will give you the best advise
Answered on Jun 27, 2014
Dr. Christian Schultheis
23 years experience Hematology and Oncology
Letrozole: Tamoxifen for 5 years followed by Letrozole would be an option. However, technically you are still premenopausal so not an option. Another treatment which is controversial is to have your ovaries removes. There is data on 10 years of tamoxifen now but you may not want to do this. The other option would be observation. Hope this helps.
Answered on Jun 27, 2014

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Biopsy: Only a biopsy can give a confirmation whether it is benign or cancer. Good luck !
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A 26-year-old member asked:
Dr. Barry Rosen
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Yes: Tamoxifen has been shown to increase the risk of uterine cancer, not unlike estrogen replacement therapy, with an incidence of ~1:500. However, this ... Read More
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Dr. Mark Hoepfner
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Maybe: There is a slight increased risk of endometrial cancer of 1 in 500 chance reported. The benefits of tamoxifen in treatment of breast cancer is much hi ... Read More
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Dr. Barry Rosen
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It can.: Studies show that women who take tamoxifen have twice the risk of uterine cancer as compared to non treated patients. However, the benefits of tamoxi ... Read More

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