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A member asked:
Does ana 1:320 with symptoms indicate lupus even if the dna was neg and sm was low? rf neg and ccp neg.
5 doctors weighed in across 3 answers
No necessarily but: it may point to the presence of other autoimmune diseases. Do note that this is merely an indicator of potential autoimmune disease and not diagnostic of anything.
Answered 11/18/2014
3.5k views
SLE diagnosis: Systemic lupus erythematosus, or lupus, is best diagnosed by an experienced rheumatologist. A high-titer ANA, >1:320 is both sensitive and specific for lupus. Other auto-antibodies can help to confirm the lupus diagnosis. Anti-Smith is highly specific for lupus but not very sensitive. Anti-dsDNA is also highly specific and tends to be seen in lupus with kidney involvement.
Answered 11/11/2015
3.5k views
Diagnosis: of lupus is based on meeting the criteria for diagnosis. Positive ANA is part of the criteria, is sensitive but not specific. Double stranded DNA is specific. Follow up with your Rheumatologist or Internist
Answered 11/22/2014
3.5k views
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