Homogeneous ana 1:320 neg double strand dna. fatigue, mouth sores, history pericardial effusion , reactive airway, knuckle pain, is this typical of lupus?

It does indeed: Whether you meet the criteria for lupus or not, this sounds suspicious. Tube tests like dsdna are often done wrong and i would let a rheumatologist's judgement have sway here when it comes to a treatment decision.

Yes but: Further testing is required to really determine lupus from similar symptoms.To other conditions..

Yes and no: Ana, arthritis oral sores and fatigue: yes. Pericarditis also, but reactive airways and -dsdna no.