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A 42-year-old female asked:

high positive ana for years and now tested elevated complement c4 and c3 but all other autoimmune antibodies are still negative. what could that be?

1 doctor answer1 doctor weighed in
Dr. Howard Feinberg
Rheumatology 37 years experience
Inflammation: Complement is a phase reactant which means it will go up with any type of inflammation. It is not specific for any one problem. A low complement is of more concern. These lab texts could mean you will eventually develop an autoimmune disease or other disease process associated with ANA. They slso may never amount to anything.

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Last updated Apr 4, 2019
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