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A 34-year-old member asked:

Clozaril (clozapine) long term side effect?

2 doctor answers2 doctors weighed in
Dr. Joseph Woods
Pathology 29 years experience
Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis.
Dr. Heidi Fowler
Psychiatry 26 years experience
Clozaril: The reason that blood work is regularly required with Clozaril is the risk of Agranulocytosis. This can be life-threatening. There are many other possible side effects with this antipsychotic medication which is primarily used in the treatment of Schizophrenia and Schizoaffective disorder.

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Last updated Jan 10, 2021

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