A member asked:

Clozaril (clozapine) long term side effect?

2 doctors weighed in across 2 answers

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis.

Answered 10/4/2018

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Dr. Heidi Fowler answered

Specializes in Psychiatry

Clozaril: The reason that blood work is regularly required with Clozaril is the risk of Agranulocytosis. This can be life-threatening. There are many other possible side effects with this antipsychotic medication which is primarily used in the treatment of Schizophrenia and Schizoaffective disorder.

Answered 1/10/2021

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