U.S. doctors online nowAsk doctors free
South Africa
A 22-year-old male asked:

Do you have to taper off one psychotic to begin the other one? from risperidone to clozapine. tell me more about side effects too, e.g. drooling.

2 doctor answers5 doctors weighed in
Dr. Mark Reynolds
Psychiatry 33 years experience
No: While it depends to some degree upon the condition that the antipsychotic is treating, you do not generally have to taper one before beginning another. In the case of going from Risperidone to clozaril, (clozapine) as Clozaril (clozapine) has to be titrated, usually you would remain on Risperdal until on enough Clozaril (clozapine) to likely control symptoms. Then you would begin lowering the Risperidone gradually.
Dr. Heidi Fowler
Psychiatry 25 years experience
Antipsychotic: Agree with Dr. Reynolds. Cross titrations are often done when changing antipsychotic medications. Due to possible withdrawal issues (such as rebound psychosis) it is often recommended that other antipsychotic be raised to a therapeutic dose before a down-titration of Clozapine.

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Educational text
Free
Talk to a doctor
24/7 visits - just $39!
50% off with $15/month membership

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Educational text
Free
Talk to a doctor
24/7 visits - just $39!
50% off with $15/month membership
Last updated Jan 10, 2021

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.