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A 50-year-old member asked:

Clozapine (clozaril) 125mg and withdrawal, can you tell me more?

2 doctor answers4 doctors weighed in
Dr. Imad Khreim
Psychiatry 39 years experience
Rebound: Clozapine is a medication with outstanding features that help control symptoms other medications otherwise failed to control. it is very serious to stop the medication without careful planning & supervision by your treating physician . the most serious withdrawal consequence is a rebound of the symptoms being treated which may take a while to re control even with clozapine restarted.see ur Dr.
Dr. Heidi Fowler
Psychiatry 25 years experience
Clozapine: Your doctor would determine if you need to come off of Clozapine. A slow off-titration is usually used for Clozapine – usually a taper of 50mg/week while under medical supervision. Starting another antipsychotic in a therapeutic dose is often recommended before the Clozapine is stopped.

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Last updated Jan 10, 2021

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