A member asked:

I have been on cymbalta (duloxetine) 60mg for last 3 years and my doctor added zoloft 50mg for 10 days then 100mg? im concerned about serotonin syndrome.

2 doctors weighed in across 2 answers

Monitor carefully: I share your concern. Serotonin syndrome is possible with this combination.

Answered 6/21/2014

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Dr. Donald Collins answered

Specializes in Family Medicine

This is possible: I would not recommend taking these 2 drugs together without close monitoring. They act by the same mechanism and have similar side effects. Ask your doctor if you could take something else or at least reduce the dose of 1 drug. Good luck!

Answered 4/24/2015

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