A 40-year-old female asked:
so i take a lot of meds cymbalta (duloxetine) tramadol naproxin amyatriplyne cyclobentaprine gabapention to name a few. could i have serotonin syndrome?
3 doctor answers
Dr. Frank Lane answered
39 years experience Psychiatry
Polypharmacy alert!: You need to check the spelling of medications you use; learn both the trade name and the generic versions. A pharmacy dispensed Clomiphene to my patient instead of what was prescribed, clomipramine, it went undetected for three months. Her ovaries were 3x normal size, hormones were off the chart and she thought she was going insane! remember "kiss"? Serotonin syndrome is a serious risk! google it!
Answered on Jun 24, 2014
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2 thanks
Dr. Dan Fisher answered
27 years experience Internal Medicine
Yes.: You are taking many meds which could in aggregate contribute to the serotonin syndrome. Might be nice to see if your meds could be consolidated or reduced.
Answered on Apr 30, 2016
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1 thank
Dr. Bassam Amawi answered
49 years experience Psychiatry
As above: I think it is important to see your PCP for reevaluation and to eliminate all none essential medication.
Answered on Apr 30, 2016
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1 comment
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1 thank
Dr. George Valdez commented
Specializes in Family Medicine
amitryptiline, cymbalta, and tramadol all have serotonin properties. tramadol is not much so is usually ok, but cymbalta and amitryptiline together may be too much, so talk with your doctor to be sure, and be aware of serotonin syndrome symptoms in case you develop at some point.
Mar 14, 2013
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Dr. Susan Feingold answered
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Call psychiatrist: You might start with the prescribing physician who i hope is a psychiatrist with this combination of psychiatric meds. If not, i would recommend you s ... Read More
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Dr. Mohammed Younus answered
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Talk to doc: Serotonin syndrome is always a concern but your psychiatrist usually takes this in to consideration while switching from one serotonin acting drug to ... Read More
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Dr. Keith Goldstein answered
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Switch to Prozac (fluoxetine): Taking alternate doses of Cymbalta (duloxetine) and Prozac while transitioning to Prozac will allow serotonin level to stabilize to minimize the risk ... Read More
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A 64-year-old male asked:
Dr. Matthew Smith answered
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Good question.: The dose of Cymbalta is high. The high dose and the combination with Trintellix is unusual and carries risks, one of which is serotonin syndrome. But ... Read More
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