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A 32-year-old member asked:

Do you know which drug is best to stop clozapine, and to reduce withdrawal cholinergic rebound?

2 doctor answers2 doctors weighed in
Dr. Erik Messamore
Psychiatry 24 years experience
Requires expert care: Withdrawing from clozapine may come with *many* potential consequences. I hope you have someone with sufficient expertise to help with the process. The anticholinergic withdrawal syndrome (AWS) is often described as flu-like malaise. Brain-permable anticholinergic meds like benztropine (Cogentin) or scopolamine would be reasonable treatments for AWS. This should be undertaken w a psychiatrist.
Dr. Heidi Fowler
Psychiatry 25 years experience
Clozapine: Starting another antipsychotic in a therapeutic dose is often recommended before the Clozapine is stopped. PLEASE only work toward a slow-off titration under psychiatric supervision.

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A 45-year-old member asked:

Which drug is best to stop clozapine and to reduce the withdrawal cholinergic rebound?

1 doctor answer2 doctors weighed in
Dr. Imad Khreim
Psychiatry 39 years experience
See ur Doctor: stopping Clozapine is a Major decision in any treatment plan, it is taken very seriously by the treating physician and all risks and benefits are weighed carefully , it cant be done over the net, you have to see your prescribing physician and discuss with him the issue. good luck and feel better

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Last updated Jan 10, 2021

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