A member asked:

How can i get rid of clozapine drug without withdrawal symptoms and cholinergic rebound?

3 doctors weighed in across 2 answers
Dr. Linda Callaghan answered

Specializes in Addiction Medicine

Taper gradually.: Depending on your dosage, your doctor can taper you gradually and safely. You will not have typical withdrawal symptoms like the opiates .

Answered 12/17/2020

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Dr. Heidi Fowler answered

Specializes in Psychiatry

PSYCHIATRIC care: Clozapine is an antipsychotic medication used as a treatment for Schizophrenia or Schizoaffective Disorder,A slow off-titration should be used for Clozapine – usually a taper of 50mg/week while under medical supervision. Starting another antipsychotic in a therapeutic dose is often recommended before the Clozapine is stopped.

Answered 1/10/2021

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