Is it safe to take ibuprofen with metoprolol, lisinopril hctz, (hydrochlorothiazide) and klor-con 10?

Not always: Ibuprofen is generally well tolerated but can worsen high blood pressure and kidney function. Since you are on multiple medications that can effect blood pressure and kidney function, i would check with your doctor first before taking Ibuprofen regularly.

Yes, but: With hypertension you need to monitor your BP and kidney function if you take it regularly.

Yes: In moderation, Ibuprofen is safe with those medications. Ibuprofen like all nsaids does go through the kidneys as does Lisinopril and hctz, (hydrochlorothiazide) so very prolonged use of the Ibuprofen is not recommended at is may cause kidney damage. Best wishes.

Yes, briefly: However, taking an NSAID such as Ibuprofen for a prolonged period can cause salt retention, hypertension, heart failure and stomach ulcers.