A member asked:

Exposure was genital to genital rubbing where woman was clothed and me naked. did 4th gen hiv test on day 66 & day 78 (negative) and rapid hiv test on day 94 again negative. syphilis eia +, rpr -ve and tppa -ve (twice) other stds neg. why syp bfp?

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Dr. Jay Park answered

Treponemal tests including TP-EIA and TP-PA are not 100% specific for syphilis; positive reactions occur variably in patients with other spirochetal diseases, such as leptospirosis, Lyme disease, yaws, etc. Nontreponemal tests are helpful in differentiating those other spirochetal diseases from syphilis.

Answered 5/9/2023

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